The Alzheimer Conundrum: Entanglements of Dementia and Aging, by Margaret Lock
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The Alzheimer Conundrum: Entanglements of Dementia and Aging, by Margaret Lock
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Due to rapidly aging populations, the number of people worldwide experiencing dementia is increasing, and the projections are grim. Despite billions of dollars invested in medical research, no effective treatment has been discovered for Alzheimer's disease, the most common form of dementia. The Alzheimer Conundrum exposes the predicaments embedded in current efforts to slow down or halt Alzheimer's disease through early detection of pre-symptomatic biological changes in healthy individuals.
Based on a meticulous account of the history of Alzheimer's disease and extensive in-depth interviews, Margaret Lock highlights the limitations and the dissent associated with biomarker detection. Lock argues that basic research must continue, but should be complemented by a public health approach to prevention that is economically feasible, more humane, and much more effective globally than one exclusively focused on an increasingly harried search for a cure.
The Alzheimer Conundrum: Entanglements of Dementia and Aging, by Margaret Lock- Amazon Sales Rank: #1443961 in Books
- Published on: 2015-10-20
- Original language: English
- Number of items: 1
- Dimensions: 9.10" h x .80" w x 6.10" l, .0 pounds
- Binding: Paperback
- 328 pages
From Publishers Weekly Lock's diligent survey of research, literature, conferences, and interviews from 2008 to 2012 follows events that led to a recasting of the phenomenon of Alzheimer disease as something to be prevented—and the lack of consensus on how to do so. She also calls for better care and social support for those living with the disease. Lock (An Anthropology of Biomedicine), McGill University professor of social studies of medicine, states that the stubborn conundrum of the most commonly diagnosed subcategory of dementia is that its biology, causes, and risk factors aren't very well understood. Lock proves that the science of the disease is just as compelling as poignant accounts from caregivers and those suffering with Alzheimer's disease. Lock highlights just how much we don't know, from problems with Alzheimer's pathology, testing, and diagnosis to the search for a drug treatment. The number of times the word ˜uncertainty' has been used in this book is remarkable, she notes. While science plugs away at solving the Alzheimer's conundrum, Lock's call for improved care and social support takes on a new urgency. (Nov.)
Review Shortlisted for the 2014 Mavis Gallant Prize for Non-Fiction, Quebec Writers' Federation"[T]houghtful . . . convincing. . . . Margaret Lock is an extremely sharp critic of the Alzheimer's scene."--W. F. Bynum, Times Literary Supplement"[A] diligent survey of research, literature, conferences, and interviews. . . . Lock proves that the science of the disease is just as compelling as poignant accounts from caregivers and those suffering from Alzheimer's disease. Lock highlights just how much we don't know, from problems with Alzheimer's pathology, testing, and diagnosis to the search for a drug treatment. . . . While science plugs away at solving the Alzheimer's conundrum, Lock's call for improved care and social support takes on a new urgency."--Publishers Weekly"[Lock] delivers key concepts in epidemiology, neuroscience and genetics in a way that is both scholarly and free of unnecessary technical details. Lock's bird's-eye view and mix of diverging sources of information is refreshing. . . . For its wide scope and balanced critical evaluation, The Alzheimer Conundrum is an inspiring read for everyone working in the field."--Eus Van Someren, Nature"Comprehensive, cogent, and densely detailed, The Alzheimer Conundrum provides a useful antidote to media hype about 'silver bullets' that are 'just around the corner' and makes an important contribution to our understanding of an achingly tragic disease that touches virtually all of us."--Glenn Altschuler, Psychology Today"The Alzheimer Conundrum: Entanglements of Dementia and Aging is a welcome addition to a body of work that has so productively explored the historical contingencies, cultural specificities, and philosophical dilemmas that surround and shape bodies and people's understandings and inhabitances of them."--Aaron Seaman, Somatosphere"The Alzheimer Conundrum is a gem for young scientists and medical students, and it will challenge them to step back from traditional models, standardised diagnostic procedures and disease specificity to adopt a broader philosophical approach: when is a disease not a disease? . . . Lock's rigorous unpacking of research studies and refusal to accept statements and conclusions from research papers at face value result in a thorough and honest appraisal of the current state of the field. It will be a great help in understanding the confusion and conflicting evidence surrounding this highly important topic."--Rose Anne Kenny, Times Higher Education"Lock's empirical account is a very welcome addition to the literature on biomedical uncertainty."--Des Fitzgerald, LSE Review of Books"[W]hether medical researchers or the general reader, this is a meaningful reading."--Liu, Economic Observer (China)"The Alzheimer Conundrum is an engaging read that, while quite granular in its detail, is never dry. . . . Lock clearly summarizes, synthesizes, and critiques the results from research in molecular biology, genetics, neuroimaging, and epidemiology."--Jason Karlawish, Health Affairs"The Alzheimer Conundrum is an eloquently reasoned, provocative work."--Choice"The strength of this book is the in-depth detailing of the limitations of the existing science of Alzheimer's. . . . This book is particularly relevant for researchers in the field of dementia: for those coming from a bio-medical perspective it may help them to be more reflexive about the choices they make in their studies, and for social scientists it may help to further understandings of and potential links with more medically focused research."--Jane Tooke, Journal of Ageing & Society
From the Back Cover
"Bringing together an anthropology of predictive medicine with a social study of science, and discussing recent biological discoveries as well as crucial public health problems, The Alzheimer Conundrum offers an insightful approach to the uncertain boundaries between aging and dementia, and brilliantly revisits the philosophical theme of the normal and pathological. Evocatively written, it is a major contribution to the understanding of one of the most perplexing and tragic issues of our time."--Didier Fassin, Institute for Advanced Study
"The Alzheimer Conundrum is a must-read for all who are interested in how society and researchers frame the investigation of Alzheimer's disease and its effects on the aging global population. Lock has woven the individual threads of the scientific discussion and debate about dementia into a magnificent tapestry, prompting us to question our assumptions and perceptions. A compelling book."--Carol Brayne, University of Cambridge
"The Alzheimer Conundrum is an eye-opening analysis of the tangles of diagnoses and treatments for Alzheimer's as they are experienced by clinicians, researchers, patients, and their families. Lock's nuanced exploration of the risk and uncertainty surrounding genetic knowledge about the brain brings the anthropology of medicine and science to an entirely new and unsurpassed level."--Emily Martin, author of Bipolar Expeditions
"A riveting plunge into the genomics and neuroscientific epidemiology of this much-feared disease, Margaret Lock's The Alzheimer Conundrum convincingly shows why scientists are unlikely to untangle the causes of Alzheimer's disease anytime soon. This superb contribution to science studies exposes the existential dilemma we all confront: what will our globalized societies do to care for our rapidly aging populations?"--Rayna Rapp, New York University
"This book is an excellent treatment of the intricacies of Alzheimer's disease--what it is, what it isn't, what it might be--and deals with its genetic, diagnostic, and predictive uncertainties. In thoroughly exploring the current state of Alzheimer's, the book sheds light on what makes most diseases complex."--Kenneth Weiss, Pennsylvania State University
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Most helpful customer reviews
8 of 8 people found the following review helpful. Great overview of AD research and the various political camps By Henry This book takes work to read as it uses many medical terms that are not familiar to the general consumer. I have a dictionary APP installed on my iPad that displays the definition as one goes simply by touching the word and it found these words so I was able to stay up with the narrative. If one is looking for something to give one hope that a solution to AD is in the immediate future than this book will be a major disappointment. The author is surveying the research landscape and its controversial nature including the political gamesmanship being played by individuals and organizations especially those committed to the arguably failed notion of BAP as the single interior brain mechanism causing AD.Bottom line - i would think this would be valuable reading for researcher in AD or medical professional. If you are a consumer and your interest is in AD as a disease and how it might someday be controlled or eliminated like one might be interested in cancer or any other ubiquitous disease thn this is an interesting read. It can serve as a guide to how one might direct contributions, organizations to support and the extent of political involvement in the funding. AS note earlier it is not for the caregiver or sufferer looking for information that can be acted upon now.
2 of 2 people found the following review helpful. The Alzheimer Conundrum presents a challenge to bio-medical scientific thinking By Susan mass ad Lock brings enormous scholarship to this fascinating book on Alzheimer's Disease. It is the story of medical science and contemporary research and raises interesting philosophical and methodological questions about our current understandings of research, knowing, causality and truth in biomedical sciences. It was my first encounter with someone who gave clear expression to what is an emerging post-modern understanding of biology and biological processes.
1 of 1 people found the following review helpful. if you really want to know about AD, read this book By Peter Magaro the best book on Alzheimer's in the last decade
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